Native MS Guided Structural Biology Center

Molecular Assemblies of the Catalytic Domain of SOS with KRas and Oncogenic Mutants.

Moghadamchargari, Z.; Shirzadeh, M.; Liu, C.; Schrecke, S.; Packianathan, C.; Russell, D. H.; Zhao, M.; Laganowsky, A.

Proc Natl Acad Sci USA 2021, 118 (12), e2022403118. https://doi.org/10.1073/pnas.2022403118.

A polymetamorphic protein.

Stewart, K.L.; Dodds, E.D.; Wysocki, V.H.; Cordes, M.H.

Protein Sci. 2013; 22(5):641-9. Request reprint © (pdf)

Solution Structure of the Nucleotide Hydrolase BlsM: Implication of Its Substrate Specificity.

Kang, M.; Doddapaneni, K.; Sarni, S.; Heppner, Z.; Wysocki, V.; Wu, Z.

Protein Science 2020, 29 (8), 1760–1773. https://doi.org/10.1002/pro.3812

De Novo Design of Protein Logic Gates.

Chen, Z.; Kibler, R.D.; Hunt, A.; Busch, F.; Pearl, J.; Jia, M.; VanAernum, Z.L.; Wicky, B.I.M.; Dods, G.; Liao, H.; Wilken, M.S.; Ciarlo, C.; Green, S.; ElpSamad, H.; Stamatoyannopoulos, J.; Wysocki, V.H.; Jewett, M.C.; Boyken, S.E.; Baker, D.

Science, 03 April 2020, 368, 6486, 78-84. DOI: 10.1126/science.aay2790

De Novo Design of Tunable, pH-driven Conformational Changes.

Boyken, S.E.; Benhaim, M. A.; Busch, F.; Jia, M.; Bick, M. J.; Choi, H.; Klima, J. C.; Chen, Z.; Walkey, C.; Mileant, A.; Sahasrabuddhe, A.; Wei, K. Y.; Hodge, E. A.; Byron, S.; Quijano-Rubio, A.; Sankaran, B.; King, N. P.; Lippincott-Schwartz, J.; Wysocki, V. H.; Lee, K.K.; Baker D.

Science, 2019, 364(6441):658-664. DOI: 10.1126/science.aav7897.

De Novo Design of Transmembrane β-Barrels

Vorobieva, A. A.; White, P.; Liang, B.; Horne, J. E.; Bera, A. K.; Chow, C. M.; Gerben, S.; Marx, S.; Kang, A.; Stiving, A. Q.; Harvey, S. R.; Marx, D. C.; Khan, G. N.; Fleming, K. G.; Wysocki, V. H.; Brockwell, D. J.; Tamm, L. K.; Radford, S. E.; Baker, D.

Science, 2021, 371 (6531), eabc8182, DOI: 10.1126/science.abc8182