Native MS Guided Structural Biology Center

Controlling protein assembly on inorganic crystals through designed protein interfaces.

Pyles H, Zhang S, De Yoreo JJ, Baker D.

Nature. 2019;571(7764):251‐256. doi:10.1038/s41586-019-1361-6

Programmable design of orthogonal protein heterodimers.

Chen, Z.; Boyken, S.; Jia, M; Busch, F; Flores-Solis, D.; Bick, M.J.; Lu, P; VanAernum, Z. L.; Sahasrabuddhe, A; Langan, R. A.; Bermeo S.; Brunette, T.J.; Mulligan, V. K.; Carter, L.P.; DiMaio, F.; Sgourakis, N.G.; Wysocki, V.H.; Baker,D.

Nature. 2018; Epub ahead of print. DOI:https://doi.org/10.1038/s41586-018-0802-y. Request reprint © (pdf)

Rapid Online Buffer Exchange: A Method for Screening of Proteins, Protein Complexes, and Cell Lysates by Native Mass Spectrometry.

VanAernum, Z.; Busch, F.; Jones, B.J.; Jia, M.; Chen, Z.; Boyken, S.E.; Sahasrabuddhe, A.; Baker, D.; Wysocki, V.

Nature Protocols 2020, DOI: 10.1038/s41596-019-0281-0

Biogenic manganese oxide nanoparticle formation by a multimeric multicopper oxidase Mnx.

Romano, C. A.; Zhou, M.; Song, Y.; Wysocki, V. H.; Dohnalkova, A. C.; Kovarik, L.; Paša-Tolić, L.; Tebo, B. M.

Nature Communications. 2017; 8: 746, DOI: 10.1038/s41467-017-00896-8. Request reprint © (pdf)

Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel.

Liu, Y.; LoCaste, C.E.; Liu, W.; Poltash, M.L.; Russell, D.H.; Laganowsky, A.

Nature Communications, 2019 Mar 22;10(1):1352. DOI 10.1038/s41467-019-09333-4.

Mass spectrometry Bound in flight.

Harvey, S. R.; Wysocki, V. H.

Nat. Chem. 2015; 7 (3), 189-190. Request reprint © (pdf)

De Novo Design of Tyrosine and Serine Kinase-Driven Protein Switches.

Woodall, N. B.; Weinberg, Z.; Park, J.; Busch, F.; Johnson, R. S.; Feldbauer, M. J.; Murphy, M.; Ahlrichs, M.; Yousif, I.; MacCoss, M. J.; Wysocki, V. H.; El-Samad, H.; Baker, D.

Nat Struct Mol Biol 2021, 28 (9), 762–770. https://doi.org/10.1038/s41594-021-00649-8.

How many human proteoforms are there?

Aebersold, R.; Agar, J. N.; Amster, I. J. A.; Baker, M. S. A.; Bertozzi, C. R.; Boja, E. S.; Costello, C. E.; Cravatt, B. F. A.; Fenselau, C.; Garcia, B. A.; Ge, Y.; Gunawardena, J.; Hendrickson, R. C.; Hergenrother, P. J.; Huber, C. G. A.; Ivanov, A. R.; Jensen, O. N.; Jewett, M. C.; Kelleher, N. L. A.; Kiessling, L. L. A.; Krogan, N. J.; Larsen, M. R.; Loo, J. A. A.; Ogorzalek Loo, R. R.; Lundberg, E.; MacCoss, M. J.; Mallick, P.; Mootha, V. K.; Mrksich, M.; Muir, T. W.; Patrie, S. M.; Pesaven

Selective Regulation of Human TRAAK Channels by Biologically Active Phospholipids

Schrecke, S.; Zhu, Y.; McCabe, J. W.; Bartz, M.; Packianathan, C.; Zhao, M.; Zhou, M.; Russell, D.; Laganowsky, A.

Nat Chem Biol 2020, 1–7. https://doi.org/10.1038/s41589-020-00659-5.

Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.

Borton, M. A.; Sabag-Daigle, A.; Wu, J.; Solden, L. M.; O’Banion, B. S.; Daly, R. A.;Wolfe, R. A.; Gonzalez, J. F.;Wysocki, V. H.; Ahmer, B. M. M.; Wrighton, K. C.

Native MS Guided Structural Biology Center

Georgia Institute of Technology