Native MS Guided Structural Biology Center

Mechanistic Insights of IscU Conformation Regulation for Fe–S Cluster Biogenesis Revealed by Variable-Temperature Electrospray Ionization Native Ion Mobility Mass Spectrometry.

Lin, C.-W.; Oney-Hawthorne, S. D.; Kuo, S.-T.; Barondeau, D. P.; Russell, D. H.

Biochemistry 2022, 61, 23, 2733–2741. https://doi.org/10.1021/acs.biochem.2c00429

De Novo Design of Obligate ABC-Type Heterotrimeric Proteins.

Bermeo, S.; Favor, A.; Chang, Y.-T.; Norris, A.; Boyken, S. E.; Hsia, Y.; Haddox, H. K.; Xu, C.; Brunette, T. J.; Wysocki, V. H.; Bhabha, G.; Ekiert, D. C.; Baker, D.

Nat Struct Mol Biol 2022, 29 (12), 1266–1276. https://doi.org/10.1038/s41594-022-00879-4.

Cupric Ions Selectively Modulate TRAAK–Phosphatidylserine Interactions.

Zhu, Y.; Schrecke, S.; Tang, S.; Odenkirk, M. T.; Walker, T.; Stover, L.; Lyu, J.; Zhang, T.; Russell, D.; Baker, E. S.; Yan, X.; Laganowsky, A.

J. Am. Chem. Soc. 2022, 144 (16), 7048–7053. https://doi.org/10.1021/jacs.2c00612.

Intrinsically Disordered Interaction Network in an RNA Chaperone Revealed by Native Mass Spectrometry.

Sarni, S. H.; Roca, J.; Du, C.; Jia, M.; Li, H.; Damjanovic, A.; Małecka, E. M.; Wysocki, V. H.; Woodson, S. A.

Proceedings of the National Academy of Sciences 2022, 119 (47), e2208780119. https://doi.org/10.1073/pnas.2208780119.

Thermodynamic Coupling between Neighboring Binding Sites in Homo-Oligomeric Ligand Sensing Proteins from Mass Resolved Ligand-Dependent Population Distributions.

Li, W.; Norris, A. S.; Lichtenthal, K.; Kelly, S.; Ihms, E. C.; Gollnick, P.; Wysocki, V. H.; Foster, M. P.

Protein Sci 2022, 31 (10), e4424. https://doi.org/10.1002/pro.4424.

Elucidation of Structure-Function Relationships in Methanocaldococcus Jannaschii RNase P, a Multi-Subunit Catalytic Ribonucleoprotein.

Phan, H.-D.; Norris, A. S.; Du, C.; Stachowski, K.; Khairunisa, B. H.; Sidharthan, V.; Mukhopadhyay, B.; Foster, M. P.; Wysocki, V. H.; Gopalan, V.

Nucleic Acids Res 2022, 50 (14), 8154–8167. https://doi.org/10.1093/nar/gkac595.

Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies.

Guaglianone, G.; Torrado, B.; Lin, Y.-F.; Watkins, M. C.; Wysocki, V. H.; Gratton, E.; Nowick, J. S.

ACS Chem Neurosci 2022, 13 (16), 2473–2482. https://doi.org/10.1021/acschemneuro.2c00313.