Center Publications: 2025

Native MS Guided Structural Biology Center

Unexpected enzymatic function of an ancient nucleic acid-binding fold, Nucleic Acids Research

Rylan R Watkins, Stella Bockelman, Anna Vradi, Kaylee Grabarkewitz, Alexa Pyun, Josephine Stark, Vicki H Wysocki, Juan D Alfonzo, Karin Musier-Forsyth, Unexpected enzymatic function of an ancient nucleic acid-binding fold, Nucleic Acids Research, Volume 53, Issue 8, 8 May 2025, gkaf328, https://doi.org/10.1093/nar/gkaf328

Q&A with Carol Robinson. J Am Soc Mass Spectrom. 2025 Jan 1;36(1):1-2. doi: 10.1021/jasms.4c00486. PMID: 39741464.

Wysocki VH, Brodbelt JS.

Roughhousing with Ions: Surface-Induced Dissociation and Electron Capture Dissociation as Diagnostics of Q-Cyclic IMS-TOF Instrument Tuning Gentleness. J Am Soc Mass Spectrom. 2025 Jan 1;36(1):187-200. doi: 10.1021/jasms.4c00417. Epub 2024 Dec 7. PMID: 39

Arslanian AJ, Wysocki VH.

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2409030121. doi: 10.1073/pnas.2409030121. Epub 2024 Dec 30. PMID: 3979304

Li W, Yang H, Stachowski K, Norris AS, Lichtenthal K, Kelly S, Gollnick P, Wysocki VH, Foster MP.

Novel multiparametric bulk and single extracellular vesicle pipeline for adipose cell-specific biomarker discovery in paired human biospecimens. bioRxiv [Preprint]. 2025 Feb 4:2024.04.18.590172. doi: 10.1101/2024.04.18.590172. PMID: 38659953; PMCID: PMC11

Hade MD, Greenwald J, Palacio PL, Nguyen KT, Shantaram D, Butsch BL, Kim Y, Noria S, Brethauer SA, Needleman BJ, Hsueh W, Wysocki VH, Reátegui E, Magaña SM.

Design of a yeast SUMO tag to eliminate internal translation initiation. Protein Sci. 2025 Jan;34(1):e5256. doi: 10.1002/pro.5256. PMID: 39692120; PMCID: PMC11653089.

Law JD, Gao Y, Wysocki VH, Gopalan V.

Identification of inhibitors of the Salmonella FraB deglycase, a drug target. Open Bio. 2025 Feb 13. doi: 10.1002/2211-5463.70001. Epub ahead of print. PMID: 39945759.

Law JD, Gao Y, Kovvali S, Thirugnanasambantham P, Wysocki VH, Ahmer BMM, Gopalan V.

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