A three hour workshop, Introduction to Native Mass Spectrometry, will be presented on October 1, 2019 in advance of the 3rd annual Ohio Mass Spectrometry and Metabolomics Symposium, held at The Ohio State University in Columbus, Ohio. P41 Resource personnel Florian Busch, Dalton Snyder, Sophie Harvey, Zac VanAernum, Alyssa Stiving and Vicki Wysocki will present an introduction to native MS methods used to help solve structural biology questions. Workshop topics include preparation/online separations, spray and instrument conditions, ion mobility, activation methods, and case studies.