A two-day short course in Native Mass Spectrometry will be presented on June 1-2, 2024 in Anaheim, CA, in conjunction with the annual American Society for Mass Spectrometry Conference.  Native MS is making significant contributions to structural biology and because of its ease of application and broad applicability often leads to an integrated approach with other structural biology tools. The course is designed to introduce the broad field of native mass spectrometry to new practitioners of native MS. 

Instructors are Vicki Wysocki, David Russell, Brandon Ruotolo, Sophie Harvey, Art Laganowski, and Michael Marty. Topics to be covered include: 

• sample preparation for native MS 
• instrumentation used for native MS - how does it differ from other MS 
• spray conditions to keep soluble complexes native 
• spray conditions for membrane protein complexes (micelles, liposomes, nanodiscs) 
• activation methods for native MS (CID, CIU, SID, UVPD, ETD/ECD/EID) 
• complementary methods (HDX, covalent labeling, crosslinking, top-down MS) 
• ion mobility for native MS • online separations approaches coupled to native MS (IEX, SEC, CE) 
• software tools for native MS • (Unidec, Impact, Pulsar, EMnIM, DynamXL, XLinkX, iFAMS) 
• case studies for protein:protein, protein ligand, RNA: protein, DNA:protein, and membrane protein complexes

For more information and registration, please visit the ASMS website.